Log of research for possible dementia reversal.

 

 ISRIB

Just a few doses of an experimental drug ISRIB produced rapid restoration of youthful cognitive abilities in aged mice.

Autophagy

Autophagy is the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier cells.

It ties tau phosphorylation and amyloid pathology to mitochondrial dysfunction and defective mitophagy.

Transcranial magnetic stimulation.

Neuromodulatory treatments

Biomarkers

Serum neurofilament light chain

Elevated cerebrospinal fluid (CSF) levels of neurofilament light chain (NfL) to distinguish FTD from primary psychiatric disorders (PPD) possibly by blood sample.

Antibiotic aminoglycosides

A class of antibiotics called aminoglycosides could be a promising treatment for frontotemporal dementia. progranulin

methylenedioxymethamphetamine (MDMA, ‘ecstasy’)

MDMA increases serotonin and facilitates the release of oxytocin,

Methylphenidate (MPH)

MPH also facilitates the release of oxytocin,